Sedation Equals Comfort, Safety, and Efficiency.
Mobile dental anesthesia serving Southern California
Contact UsVine Wellness & Longevity
Fully virtual, medical-assisted weight loss, hair loss, sexual health, and much more.
Learn MorePartner With Us to Elevate Your Practice
We bring hospital-grade anesthesia directly to your dental office.
For the DentistsHappy with your experience? Share it with others.
Write a ReviewFor Patients
Experience pain-free dentistry with our intravenous sedation services. We work alongside your dentist to ensure your comfort and safety throughout every procedure.
Learn MoreFor Dentists
Partner with Dr. Istaphanous to bring hospital-grade anesthesia directly to your practice. Enhance patient care and expand the procedures you can offer.
Learn MoreWhy Sedation?
Comfort, Safety & Efficiency
Intravenous sedation allows your dentist to perform complex, multi-visit procedures in a single appointment — while you remain relaxed, comfortable, and free from anxiety.
Meet the Doctor
Dr. George Istaphanous MD
Board-Certified Anesthesiologist
Dr. Istaphanous is a board-certified anesthesiologist with extensive experience in dental and pediatric anesthesia. He brings hospital-grade care directly to dental offices throughout Southern California.
- Board Certified in Anesthesiology
- Fellowship-trained in Pediatric Anesthesia
- Fellowship-trained in Pediatric Cardiac Anesthesia
- Member, American Society of Anesthesiologists
- Member, Society for Pediatric Anesthesia



Latest Articles
How Dental Sedation Benefits Patients with Anxiety
Read MoreBased on 250 reviews on Google
What Our Patients Say
Krishan T
October 2, 2026
Greg Mcguff
September 30, 2026
Dr Stefanus showed great care for my elderly mom before, during and after her procedure.
Karla Soto
September 30, 2026
We had a great experience with Dr. Istaphanous and the anesthesia team! As a parent, I was nervous about my daughter going under anesthesia, but they made everything much easier than we expected. They explained every step from start to finish, which helped me feel informed and reassured throughout the process. They also gave us clear, detailed instructions for caring for her at home, so I felt confident about what to expect afterward. I especially appreciated Dr. Istaphanous checking in to see how she was doing after. Thank you to the entire team for taking such great care of my daughter and making a stressful day feel more manageable. We're so grateful!
Jessica Grace
September 29, 2026
We are incredibly grateful for the wonderful care our 7-year-old son received from Dr.George. He was patient, kind, and incredibly reassuring throughout the entire process. As parents, it can be very difficult to see your child go through a procedure, but his calm and compassionate approach helped ease both our son's fears and our own. He took the time to make our son feel comfortable and safe, and we truly appreciated the patience and care he showed him. His professionalism and genuine concern for our child made a stressful experience much easier for our family. We highly recommend Dr.George for any family looking for an anesthesiologist who is knowledgeable, compassionate, and especially wonderful with children. We are very thankful for everything he did for our son!
Joni Balan
September 26, 2026
Dr Istaphanous, was spectacular! His bedside manner was among the best I've seen in any medical profession. Everything from the second we meet to the follow up the day after the procedure was nothing short of exceptional! Thank you
christine Harris
September 25, 2026
Excellent! The best dental expérience I ever had. Woke up after surgery was done. Dr Istapahnous is very professional. I highly recommend him !
Cyndi Woodgrift
September 19, 2026
On September 16, 2026, I had dental implants placed, and I wanted to share my experience. My dentist, Dr. Loberg, is absolutely amazing. I was especially nervous about being sedated because I have never handled sedation well in the past. Dr. Loberg highly recommended Dr. George, the anesthesiologist, and couldn't have spoken more highly of him. I am so grateful for that recommendation because Dr. George was exceptional. From the moment he met me, Dr. George demonstrated outstanding professionalism, compassion, and patience. He listened carefully to my concerns, understood how anxious I was, and took the time to explain everything and reassure me. His calm and caring manner immediately helped me feel safe and comfortable. The entire process was so smooth that I fell asleep without any difficulty and woke up feeling as though I had simply taken a nap. I experienced no discomfort during the procedure, and Dr. George's attentive care made a tremendous difference in my experience.
Charlene Forehan
September 17, 2026
Dr. Istaphanous was so kind and patient. I had a wonderful experience during my dental procedure with him. If I ever need anesthesia again, he will definitely be the one to take care of me.
SERA TACHIKI
September 12, 2026
Dr. George was professional and personable. He was very helpful to let the family know what was happening with the procedure as well as the progress of the patient which made it a lot less stressful for the family. Really appreciate his willingness to go out of his way to help.
Tyona Benton
September 11, 2026
Staff is very nice
Get in Touch
Ready to schedule a consultation or have questions? Contact us today and our team will be happy to help.
Address
26800 Crown Valley Pky, Suite 485, Mission Viejo, CA 92691
Phone
(949) 478-2741Email
[email protected]Hours
Monday–Friday 9:00am–6:00pm, Saturday 9:00am–1:00pm
Please note: we do not accept fax submissions for appointment requests.
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